Strobilurins F, G and H, three new antifungal metabolites from Bolinea lutea. II. Structure determination.

To date six antifungal antibiotics of the strobilurin-type are known (Scheme 1): Strobilurin A (1)1>2) which is identical with mucidin3), strobilurin B (2)ia\ strobilurin C (3)4), methoxymucidin (4)5), hydroxystrobilurin D6) and strobilurin E7). They contain an unsaturated side chain with a terminal (£)-/?-methoxyaerylate moiety and differ usually in their aromatic substitution. In the preceding paper8) we described the fermentation, isolation and biological properties of three new strobilurins F, G and H